Constantine is elected pope. Born in Syria under the Umayyad Caliphate, he will be the only pope to adopt such an "eastern" name, a name used regularly by patriarchs and emperors in the Byzantine Empire. Constantine may be the only pope to come from the Assyrian ethnic group - the same semitic tribe which created the Assyrian Empire which existed from the 24th through the 7th century BCE.
He will also be the last pope to visit the city of Constantinople until Pope Paul VI in 1967, at which time the city is named Istanbul, not Constantinople. This trip will be made to settle a dispute between eastern and western Christianity with Emperor Justinian II. The fact that Constantine is able to identify with eastern thinking and approaches probably makes the negotiations much easier.
Justinian's successor, Philippikos Bardanes, will be an adherent of Monothelitism which Pope Constantine will refuse to support, leading to more problems, but Philippikos Bardanes doesn't last long as emperor and peaceful relations are restored again.