Battle of Megiddo: Egyptian forces under Thutmose III fight a large Canaanite coalition under the King of Kadesh at Meggido in current-day Israel. This battle is noteworthy because it's the first historical battle to be recorded in what scholars believe is fairly reliable detail.
The Egyptians completely rout the Canaanites, who try to take refuge in the city of Megiddo, leading to the subsequent Siege of Megiddo which lasts seven months. Finally Megiddo surrenders to Thutmose III, but the King of Kadesh escapes. Because of this battle the Egyptians will have a strong presence in the region, leading to the greatest expanse that the Egyptian Empire will ever achieve.